New York City Police Detective Sara Pezzini is the latest in a long line of bearers of the Witchblade, a mysterious artifact that takes the form of a deadly and powerful mystical gauntlet. Bound by destiny, the Witchblade chooses one woman in a generation, who must stand between the forces of Light and Dark and preserve The Balance. Now Sara must try to control the Witchblade and uncover its secrets, even as she investigates the city's strangest, most supernatural crimes.